Lipids are a diverse group of hydrophobic organic molecules, which include fats, oils, sterols, and waxes. Degradation of nucleotides result in xanthine then uric acid production in purines, while pyrimidines produce the amino acids, β-alanine, and β-aminobutyrate. For thymine, a part of deoxyribonucleotides, ribonucleoside reductase is required to reduce the ribose moiety. Synthesis of pyrimidine nucleotides also follows different reactions, producing uridine monophosphate (UMP), which is converted to uridine triphosphate (UTP) and cytidine triphosphate (CTP). Purine synthesis is regulated in the 1st 2 steps. The de novo pathway generates inosine monophosphate (IMP), which is the precursor of adenosine monophosphate (AMP) and guanosine monophosphate (GMP).
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Purine nucleotide synthesis follows a series of reactions using carbon donors, amino acids (e.g., glutamine, aspartate), and bicarbonate. Purines include adenine and guanine, while pyrimidines include thymine (in DNA), uracil (in RNA), and cytosine. Purines and pyrimidines are heterocyclic aromatic compounds, which, along with sugar and phosphate groups, form the important components of nucleotides. Radiation therapy is used in adults but not in children, and stem cell transplantation is used for patients with aggressive disease. Management is with chemotherapy or targeted drugs. Diagnosis is made by lymph node biopsy, bone marrow biopsy, or both. T-cell NHLs include adult T-cell lymphoma and mycosis fungoides. B-cell NHLs include diffuse large B-cell lymphoma, follicular lymphoma, Burkitt lymphoma, mantle cell lymphoma, and marginal zone lymphoma. Clinical features include lymphadenopathy and hepatosplenomegaly, but some individuals present with extranodal involvement and abnormal lab findings. Like Hodgkin lymphoma, which has distinct pathologic features and treatments, NHL often presents with constitutional signs of fever, night sweats, and weight loss. Most pediatric cases are aggressive and high-grade (but curable) in adults, low-grade subtypes are more common. Non-Hodgkin lymphomas (NHLs) are a diverse group of hematologic malignancies that are clonal proliferative disorders of mature or progenitor B cells, T cells, or natural killer (NK) cells. The treatment is to administer fluids with tonicity similar to those lost isotonic fluids are used for volume depletion, and hypotonic fluids are used for dehydration. Management requires differentiation between these 2 conditions. The diagnosis of these imbalances is based on lab findings in addition to clinical symptoms and signs, which can be subtle and unreliable. The clinical presentation has relatively nonspecific symptoms but will ultimately cause low blood pressure if severe.
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Volume depletion can be caused by GI losses, renal losses, bleeding, poor oral Na intake, or third spacing of fluids. Dehydration is primarily caused by decreased water intake and presents with increased thirst and can progress to altered mental status and low blood pressure if severe.
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Volume depletion (also known as hypovolemia) refers to a loss of both water and Na, whereas dehydration refers only to a loss of water. Offering the strength of a serum and the silky hydration of a cream, this firming formula is powered by Heparan Sulfate Analog (HSA) to help hydrate the skin, while supporting the skin’s natural ability to promote collagen and elastin.Volume status is a balance between water and solutes, the majority of which is Na.
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Reveal a more youthful-looking complexion with Dermal Contour Pressed Serum from Sente Labs. Formulated with Skin-Firming Duo Dermatan Sulfate Analog (DSA) and Chondroitin Sulfate Analog (CSA) technology to support the skin’s natural ability to promote collagen and elastin production for firmer, younger-looking skin. Formulated with patented Heparan Sulfate Analog (HSA) technology to rapidly and profoundly hydrate and strengthen the skin’s natural ability to repair itself. A lightweight, 2-in-1 hybrid facial serum that firms and hydrates the skin.